Title Lactoferrin enhances opioid-mediated analgesia via nitric oxide in the rat spinal cord Authors
نویسندگان
چکیده
Lactoferrin (LF) is a multifunctional protein that is found in milk, neutrophils, and other biological fluids, and its receptors have also been identified in the central nervous system. Recently, we found that bovine milk-derived LF (BLF) produced analgesia via μ-opioid receptor-mediated response in the spinal cord. However, the precise mechanism of this analgesic effect remains unclear. In this study, spinally applied BLF produced analgesia that was reversed by co-administration with a nitric oxide (NO) synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), during phase 1 and phase 2 in the formalin test. Spinal co-administration of a μ-opioid receptor agonist, morphine, with Copyright (c) 2003 by the American Physiological Society. Articles in PresS. Am J Physiol Regul Integr Comp Physiol (April 17, 2003). 10.1152/ajpregu.00760.2002
منابع مشابه
Lactoferrin enhances opioid-mediated analgesia via nitric oxide in the rat spinal cord.
Lactoferrin (LF) is a multifunctional protein that is found in milk, neutrophils, and other biological fluids, and its receptors have also been identified in the central nervous system. Recently, we found that bovine milk-derived LF (BLF) produced analgesia via a mu-opioid receptor-mediated response in the spinal cord. However, the precise mechanism of this analgesic effect remains unclear. In ...
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